Fig. 5
From: Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function
Presynaptic Ena function regulates spontaneous but not evoked glutamate release. a, Current clamp recordings from muscle 6 (abdominal segments 3 and 4) revealed similar EJP amplitude and kinetics between the AP4mito control and FP4mito under the control of the neuronal 1407-GAL4 driver (top), yet very distinct spontaneous mEJPs (bottom). The mean EJP amplitude was not altered by enaLOF (b), whereas mEJP frequency (c) and amplitude (d) were both significantly increased. D’, An distribution of mEJP amplitude (an alternate depiction of data in d) shows a shift to the right in enaLOF animals with abnormally high mEJPs (indicated by five-pointed star), and the mean mEJP amplitude was significantly increased (indicated by filled arrows). Results corresponding to control are depicted with a black arrow and blue distribution; results corresponding to enaLOF are depicted with a gray arrow and orange distribution). * P < 0.05, as determined by Welch’s t-test, n = 3 animals and 6 NMJs for control, n = 4 animals and 7 NMJs for enaLOF