Table 1 Known factors that regulate microglia formation or survival
Factors | Findings | References |
|---|---|---|
PU.1 | Mice were devoid of microglia in the absence of PU.1 due to a reduction in early myeloid progenitors. | McKercher et al. 1996 [7] |
CSF1R | Csf1r knockout mice showed no microglia formation. | Dai et al. 2002 [8] Ginhoux et al. 2010 [9] Bruttger et al. 2015 [10] |
TLR4 | TLR4-deficient mice display reduced numbers of microglia in the retina. | Dando et al. 2016 [11] Noailles et al. 2019 [12] |
IRF8 | IRF8-deficient mice display reduced numbers of microglia during both development and adulthood. | Holtschke et al. 1996 [13] Kierdorf et al. 2013 [14] |