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Fig. 4 | Neural Development

Fig. 4

From: sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS

Fig. 4

Absence of robo or robo2 result in mis-migrating and morphological irregularities in lch5 chordotonal neurons. a. WT stage 16 embryo labeled with anti-22C10 showing the lch5 cluster in a lateral position in the embryo and the five lch5 neurons in an evenly-spaced diagonal row facing the dorsal-posterior edge of the embryo. b. Blown-up view of boxed region in A showing two abdominal hemisegments of PNS neurons. Black arrows point to lch5 neurons and white arrowheads point to the v’ch1 neuron, just ventral to the lch5 cluster. c. robo mutant (robo570) embryo showing lch5 neurons displaying an irregular morphology. d. Blown-up view of boxed region in C showing two abdominal hemisegments of PNS neurons. Black arrowheads show lch5 neurons with an irregular morphology and white arrowheads point to the v’ch1 neuron. e. robo2 mutant (robo2x135) embryo showing lch5 neurons not migrating as far ventral. f. Blown-up view of boxed region in E showing two abdominal hemisegments of PNS neurons. Red arrow shows lch5 neurons that are further from the v’ch1 neuron (white arrowhead). g. Quantification of percent total lch5 clusters displaying irregular morphology in WT, robo570, and robo2x135. h. Quantification of percent total mis-migrating lch5 clusters in WT, robo570, and robo2x135. Number of abdominal lch5 clusters scored for each genotype above each bar (n). **p < 0.05 based on a G-test of statistical independence

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