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Fig. 11 | Neural Development

Fig. 11

From: Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development

Fig. 11

ipRGCs are born earlier than Brn3a positive RGCs. a, Top, GFP or Brn3a immunohistochemistry (green) of retinas from Adult Opn4Cre/+;ZEG, Opn4LacZ/+; Opn4-GFP and Opn4Cre/+ animals exposed to EdU (magenta) at different developmental stages. White arrow heads point to examples cells co-labeled with GFP or Brn3a and EdU. Bottom, Schematic of cell types labeled green in each experiment. b Accumulation plot of proportion of ipRGCs or Brn3a RGCs that are EdU positive when exposed to EdU at different embryonic timepoints. Accumulation was calculated based on adding together the proportion data calculated for each timepoint. c Proportion of ipRGCs or Brn3a RGCs that are EdU positive when exposed to EdU on specific embryonic day. Graphs are Mean ± SD, n = 3–4 retinas per timepoint. Scale bar is 100 μm

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