Fig. 11
P20 Car8wdl mice have normal muscle strength but abnormal muscle coordination. (a) Despite an ataxic gait, grip strength is not impaired in Car8wdl adult mice (n = 8 per genotype). p = 0.8120; Student’s t test; Mean ± SEM. (b) Schematic of EMG electrode locations. TA = tibialis anterior; GC = gastrocnemius. (c) Bouts of TA muscle activity in Car8wdl mice (n = 6) appear longer than in control mice (n = 6). The scale bar represents 25 ms. (d) Car8wdl (n = 6) TA muscles fire longer individual bursts of activity, but not more frequently, than control mice (n = 6). The number of bursts and spikes are denoted in the graphs by the abbreviation, no. Bursts/Time, p = 0.3038; Burst length, * p < 0.05; Spikes/Burst, ** p < 0.01; Student’s t test; Mean ± SEM
(e) Example EMG traces and waveform correlograms of P20-P24 control mice, showing the out of phase firing of TA and GC muscles, and of P20-P24 Car8wdl mice, showing overlap between TA and GC muscle firing. The scale bar represents 500 ms