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Fig. 11 | Neural Development

Fig. 11

From: Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse

Fig. 11

P20 Car8wdl mice have normal muscle strength but abnormal muscle coordination. (a) Despite an ataxic gait, grip strength is not impaired in Car8wdl adult mice (n = 8 per genotype). p = 0.8120; Student’s t test; Mean ± SEM. (b) Schematic of EMG electrode locations. TA = tibialis anterior; GC = gastrocnemius. (c) Bouts of TA muscle activity in Car8wdl mice (n = 6) appear longer than in control mice (n = 6). The scale bar represents 25 ms. (d) Car8wdl (n = 6) TA muscles fire longer individual bursts of activity, but not more frequently, than control mice (n = 6). The number of bursts and spikes are denoted in the graphs by the abbreviation, no. Bursts/Time, p = 0.3038; Burst length, * p < 0.05; Spikes/Burst, ** p < 0.01; Student’s t test; Mean ± SEM

(e) Example EMG traces and waveform correlograms of P20-P24 control mice, showing the out of phase firing of TA and GC muscles, and of P20-P24 Car8wdl mice, showing overlap between TA and GC muscle firing. The scale bar represents 500 ms

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