Fig. 10

Car8^wdl mice have a high-stepping, tippy-toe gait that is indicative of dystonia. (a) Sample footprints from CatWalk for 3 control mice and 3 Car8^wdl mutant mice. Also see Additional file 1: Movie S1 and Additional file 2: Movie S2. (b) Analysis of the footprints (n = 3 per genotype) recorded on CatWalk show that print length is not affected in Car8^wdl mice (Forelimbs (p = 0.4444): control 0.8322 ± 0.01472 cm, mutant 0.8089 ± 0.02321 cm; Hindlimbs (p = 0.1977): control 0.8295 ± 0.02899 cm, mutant 0.7638 ± 0.03112 cm), but print width is reduced (Forelimbs (p = 0.0038): control 0.7811 ± 0.02154 cm, mutant 0.5755 ± 0.02632 cm; Hindlimbs (p = 0.0017): control 0.7180 ± 0.01177 cm, mutant 0.5919 ± 0.01220 cm). Accordingly, compared to control mice (Forelimbs: 0.2675 ± 0.001582 cm; Hindlimbs: 0.2505 ± 0.01276 cm), the print area is reduced in Car8^wdl mice (Forelimbs: 0.1990 ± 0.02576 cm, p = 0.0567; Hindlimbs: 0.1934 ± 0.01509 cm, p = 0.0445). *** p < 0.01 and **** p < 0.0001 Student’s t test; Mean ± SEM