Fig. 8

Routing of optic tract-traversing cholinergic axons WT and math5^−/−. Examples of coronal sections through the thalamus are shown at the level of caudal dLGN (top panels) and middle dLGN (bottom panels) for WT (A & C) and math5^−/− (B & D). High power views at the level of the cerebral peduncle and the border of dLGN/vLGN are shown in the right hand panels. In WT (A & C), cholinergic axons travel with the optic tract near the cerebral peduncle (A” & C″), and continue dorsally along the outer border of the vLGN and dLGN (A’ & C′). In math5^−/− (B & D), cholinergic axons emerge near the cerebral peduncle (B″ & D”), but are displaced medially in the caudal dLGN (B′) and middle dLGN (D’). Scale bars = 200 μm (left panels), 50 μm (right panels)