Fig. 11

The pattern of PBG terminal arbors in dLGN in the presence and absence of retinal input (math5^−/−). Examples of coronal sections depicting tdT-labeled terminal arbors in dLGN after an injection of FLEX-AAV-ChIEF-tdT virus into the left PBG in a WT (A & C) and math5^−/− (B & D) ChAT-Cre mouse. Left panels depict low power images, showing the distribution of PBG arbors in caudal (top panel), middle, and rostral (bottom panel) dLGN. Middle panels show a higher power view depicting PBG arbor distribution within an example section of dLGN. Dotted lines delineate the boundaries of dLGN. Right panels show high power views of PBG arbors. a In ipsilateral dLGN of WT, arbors are restricted to a small region in the dorsomedial region of the middle and rostral dLGN, just beneath the optic tract (A1 & A1’). b In the ipsilateral dLGN of math5^−/−, PBG arbors are were displaced into the medial regions of the nucleus (B1 & B1’). c In the contralateral dLGN of WT, arbors are distributed throughout the caudo-rostral extent of dLGN (C1, C1’). d In the contralateral dLGN of math5^−/−, arbors are distributed throughout the caudo-rostral extent. Scale bars = 200 μm (left panels) and middle 30 μm (right panels)