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Fig. 4 | Neural Development

Fig. 4

From: Development, functional organization, and evolution of vertebrate axial motor circuits

Fig. 4

Diverse function of axial motor circuits in tetrapods. a Simplified diagram of respiratory networks for inspirational breathing. Rhythm generation in the preBötzinger (preBötz) complex is relayed to rostral ventral respiratory group (rVRG) neurons. rVRG neurons target PMC neurons and HMC neurons in the spinal cord. Connections between preBötz and rVRG neuron relies on Dbx1 gene function. b-d Role of axial motor circuits in spinal alignment. b Axial muscles and nerves associated with vertebrae. Box indicates region magnified in panel c. c Consequences of Runx3 mutation on the projection of proprioceptive sensory neurons in the spinal cord. Loss of Runx3 leads to a loss of projections to MNs, and likely other classes of spinal interneurons. d Effect of Runx3 mutation on vertebral alignment in adult mice

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