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Fig. 4 | Neural Development

Fig. 4

From: Tcf7L2 is essential for neurogenesis in the developing mouse neocortex

Fig. 4

The loss of Tcf7L2 in the embryonic cortex leads to downregualtion of canonical Wnt signalling and reduction of radial glial cells and intermediate progenitors. a-d‘ β–galactosidase immunofluorescence in the cortical VZ in BAT-Gal Wnt reporter mice is reduced after inactivation of Tcf7L2 alone (c-c‘) or upon simultaneous deletion of Tcf7L1 and Tcf7L2 (d-d‘). Inactivation of Tcf7L1 alone had a little effect on BAT-Gal Wnt reporter (b-b“). Panels in a‘ display magnified framed rectangles in a. e-g Quantifications of BAT-Gal+, Sox2+ RGCs and Tbr2+ IPCs showing an average from three independent experiments with standard deviations. Student’s paired t-test: *p < 0.05, **p < 0.01, ***p < 0.001 compared to controls, n = 6. P-values between Tcf7L2 and Tcf7L1/Tcf7L2 mutants are: BAT-Gal+ p = 0.06, Sox2+ p = 0.34, Tbr2+ p = 0.80 showing no statistical significance. h-k“ Double immunofluorescent labelling of Sox2+ RGC and Tbr2+ IPCs. Dashed lines represent potential ventricular lining

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