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Fig. 2 | Neural Development

Fig. 2

From: Tcf7L2 is essential for neurogenesis in the developing mouse neocortex

Fig. 2

Hypoplasia of the neocortex and disruption of the ventricular zone in D6-Cre/Tcf7L1fl/fl/Tcf7L2fl/fl mutants. a Smaller cortical lobes in Tcf7L1/Tcf7L2 double mutants dissected from newborn mice (P0). Arrows illustrate the length of cortices. The perimeter of cortices is labeled with a dashed line. b Statistical analysis of cortical size (perimeter) in Tcf7L2 single and Tcf7L1/Tcf7L2 double mutants with standard deviations. Student’s paired t-test: ***p < 0.001 compared to controls; controls n = 8 and either mutants n = 5. The size of Tcf7L1 cortices was not tested (NT). c-f‘ Hematoxylin-eosin staining of coronal sections at P0 from controls (c-c‘), Tcf7L1 single mutants (d-d‘), Tcf7L2 single mutants (e-e‘) and Tcf7L1/Tcf7L2 double mutants (f-f‘). Arrows point at the disrupted VZ and asterisks show the impaired hippocampus

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