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Fig. 8 | Neural Development

Fig. 8

From: Monocular enucleation alters retinal waves in the surviving eye

Fig. 8

 A model to explain the relationship between pairwise RGC correlation levels and retinogeniculate refinement. a - d Illustrations of horizontal sections at P10 with retinogeniculate laminae shaded. Ipsilateral inputs are shown in magenta; contralateral inputs are shown in green. A = anterior, P = posterior, M = medial, L = lateral. In binocular ferrets, the ipsilateral projection is condensed and segregated from the contralateral projection by P10 (a). In monocular ferrets, the surviving ipsilateral projection is greatly expanded following the elimination of contralateral input (b). In binocular ferrets when retinal waves are blocked, eye-specific segregation fails and afferent targeting is abnormally expanded (c). In monocular ferrets when retinal waves are blocked, expansion of the ipsilateral projection is disrupted (d). e Binocular ferrets have longer RGC bursts that result in higher pairwise RGC correlation levels. Higher levels of correlated RGC activity decreases intra-eye competition, which can better facilitate the formation of eye-specific laminae during inter-eye competition. f Monocular ferrets have shortened RGC bursts that result in lower pairwise RGC correlation levels. The reduction in pairwise RGC correlations increases intra-eye competition, resulting in afferent spread and expanded ipsilateral laminae. Blue dashed line represents RGC correlation levels for the binocular condition. g-h EPI treatment decorrelates RGC activity and disrupts intra-eye and inter-eye competition, resulting in random afferent targeting and similar ipsilateral projection size in EPI-treated binocular and monocular ferrets. Blue and red dashed lines represent RGC correlation levels for the untreated binocular and monocular conditions respectively

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