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Fig. 1 | Neural Development

Fig. 1

From: Monocular enucleation alters retinal waves in the surviving eye

Fig. 1

Effects of removing inter-eye competition on RGC activity. a An illustration of the enucleation protocol and MEA used for recording retinal waves. b Raster plots of wave activity from the retina of a binocular (top) and a monocular (bottom) ferret. c The RGC activity from highlighted periods shown in b on a finer time scale. d-f) Plots showing the difference in burst duration (s) (binocular, 2.39 ± 1.32; monocular, 1.67 ± 0.99; mean ± STD; T(2168) = 4.91, P = 9.9609 × 10− 7, linear mixed-effects model with log transformation) (d), number of spikes within a burst (binocular, 60.16 ± 53.26; monocular, 44.87 ± 39.82; mean ± STD; T(2168) = 2.92, P = 0.0036, linear mixed-effects model with log transformation) (e), and firing rate (spikes/s) (binocular, 1.19 ± 1.19; monocular, 0.86 ± 0.84; mean ± STD; T(2176) = 2.49, P = 0.0128, linear mixed-effects model with log transformation) (f), between RGCs from retinae of binocular or monocular ferrets. g - h Plots of RGC burst duration for all retinae recorded at a temperature of 34 °C (binocular, 2.76 ± 1.42; monocular, 1.82 ± 0.91; mean ± STD; T(1317) = 3.90, P = 9.952 × 10− 5, linear mixed-effects model with log transformation) (g) and 37 °C (binocular, 1.79 ± 0.83; monocular, 1.46 ± 1.07; mean ± STD; T(850) = 3.37, P = 0.00077, linear mixed-effects model with log transformation) (h). Dashed lines indicate group means. The heights of the box plots extend between the 25th and the 75th percentiles of the data. The horizontal bar and cross mark indicate the median and mean, respectively. Outliers are shown as circles and are data points that are 1.5 times higher than or 1.5 times lower than the interquartile range. The box plot whiskers extend to the most extreme data points that are not outliers. Binocular, N = 1178 cells, 13 retinae; Monocular, N = 1001 cells, 11 retinae. * = P < 0.05, ** = P < 0.01, *** = P < 0.001, **** = P < 0.0001

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