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Fig. 8 | Neural Development

Fig. 8

From: FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord

Fig. 8

Coexposure of neural progenitor cells to FGF8 and Shh signals favors co-expression of Olig2 and Nkx2.2. a-f: Immunodetection of Olig2 (blue) and Nkx2.2 (red) on transverse E2.5 neural tube sections after electroporation at E1.5 with FGF8 (a, d), Shh (b, e) or both FGF8 and Shh expression vectors (c, f). d, e and f show higher magnification of the areas framed in (a, b) and (c), respectively. Note that Olig2 expression is detected in most of the Nkx2.2 positive cells induced by overexpression of both FGF8 and Shh (arrows in f, f′ and f″) but not in Nkx2.2 positive cell induced by overexpression of Shh alone (arrows in e, e’ and e”). Scale bars = 50 μm in a-c, 25 μm in d-f

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