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Fig. 2 | Neural Development

Fig. 2

From: Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes

Fig. 2

Conditional deletion of Lhx2 and Pax6 from E8.5 recapitulates the lateralization of medial fates seen in the double null mutants. a-d Tamoxifen was administered at E8.5 to Control (a), CreER;Pax6 lox/lox(b), CreER;Lhx2 lox/lox(c), and CreER;Lhx2 lox/lox ;Pax6 lox/lox (d) animals, and the embryos were harvested at E12.5. Coronal sections were examined for Wnt8b expression at rostral, mid, and caudal levels of sectioning. Wnt8b expression is restricted to the medial cortical neuroepithelium in control and Pax6 lox/lox brains (a, b). In Lhx2 lox/lox brains, a small region of lateral neuroepithelium remains Wnt8b-negative (region between open arrowhead and dashed line, c). In the double conditional mutants, Wnt8b expression extends almost upto the pallial-subpallial boundary (dashed lines, c, d). Scale bar is 200 μm

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