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Fig. 6 | Neural Development

Fig. 6

From: Two Drosophila model neurons can regenerate axons from the stump or from a converted dendrite, with feedback between the two sites

Fig. 6

Distal axotomy often leads to formation of two axons from two locations in Class IV ddaC neurons. a An axon of a Class IV ddaC neuron was axotomized (orange arrow) more than 30 μm from the cell body. An asterisk indicates the dorsal bipolar md neuron (dbd). b The same neuron was imaged 96 h after injury. One of the dendrites converted to an axon as indicated by the dashed line. c The inset shows the same cell as in A and B, but at a different depth of focus to visualize the re-growing axon joining the nerve. d Out of 17 axotomized neurons, 4 neurons regenerated from the axon stump only, 4 neurons regenerated from the dendrite only and 9 neurons regenerated from both locations. e An axon of a Class IV ddaC neuron was severed at least 65 μm from the cell body; the cute site is indicated with an orange arrow. f The same neuron was imaged 96 h after injury. In this example, the remaining axon stump regenerated and joined the motor nerve bundle. g Out of 18 injured neurons, 10 neurons regenerated from the stump; 5 neurons regenerated from the dendrite and 3 neurons regenerated from both sites

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