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Fig. 6. | Neural Development

Fig. 6.

From: Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord

Fig. 6.

EphrinB3 inversely controls the ratio between pMN and p3 progenitors. a, b. Transverse sections of Efnb3 +/- (a) and Efnb3 -/- (b) E11.5 embryos were immunostained to detect Olig2 (red) and Nkx2.2 (blue). c. The number of Olig2+, Nkx2.2+ and Olig2+/ Nkx2.2+ (double) progenitors was quantified. Total refers to the sum of Olig2+ and Nkx2.2+ progenitors. d. Quantification of the proportion of sections showing an overlap in Efnb3 +/- and Efnb3 -/- embryos. e. Example of spatial positioning of Olig2+and Nkx2.2+ progenitors in an overlap situation in an Efnb3 -/- embryo. f. Quantification of the surface of overlap between Olig2+ and Nkx2.2+ domains in Efnb3 +/- and Efnb3 -/- embryos. Error bars indicate s.e.m. (n=5 embryos per genotype); *P<0.05; **P<0.01; (Mann-Whitney-Wilcoxon test), ns: non significant. Scale bars: 50 μm.

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