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Fig. 1 | Neural Development

Fig. 1

From: Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance

Fig. 1

Immunohistochemical analysis of TCA development in Plxna2; Plxna4 single and double mutant P0 brains. Immunostaining for neurofilament (red) confirms the presence of a Sema6a-mutant-like TCA defect in Plxna2; Plxna4 double mutant postnatal brains (d; filled arrowhead), while no abnormal thalamic projections in the vTel are observed in either Plxna2 or Plxna4 single mutants (a, b). Additionally, misrouted TCAs are not present in Plxna2; Plxna4 double heterozygous brains (c). Some TCA guidance defects, similar to those observed in double mutant brains but restricted to only a few thalamic fibers, also characterize Plxna2 +/− ; Plxna4 −/− and Plxna2 −/− ; Plxna4 +/− postnatal brains (e, f; empty arrowheads). Scale: 500 μm

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Neural Development

ISSN: 1749-8104