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Fig. 3 | Neural Development

Fig. 3

From: The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development

Fig. 3

TACC3 and XMAP215 interacts to promote axon outgrowth. a, b, Combinatorial reduction or elevation of TACC3 and XMAP215 levels reveals synergistics in axon outgrowth. Knocking down both TACC3 and XMAP215 (n = 312) showed significant reduction in axon length in comparison to control (n = 219), TACC3 KD (n = 487) and XMAP21 KD alone (n = 312) (a). Overexpression of both (n = 654) showed significant increase in axon length in comparison to control (n = 1288) and TACC3 OE (n = 1585), while double overexpression had no additive effect in comparison to XMAP215 OE (n = 1227) (b). c, d, Reduced axon outgrowth in TACC3 KD (n = 289) (c) or XMAP215 KD (n = 299) (d) neurons is rescued by the overexpression of XMAP215 (n = 313) or TACC3 (n = 397), respectively. *p < 0.05, **p < 0.01, ***p < 0.001. ns not significant. n = axon number

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Neural Development

ISSN: 1749-8104