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Fig. 5 | Neural Development

Fig. 5

From: Akirin2 is essential for the formation of the cerebral cortex

Fig. 5

Cell cycle analysis of cortical progenitors in Akirin2 knockout embryos. Pregnant dams were injected with EdU at E10 and embryos collected 12 h later at E10.5 (a, b), or injected at E10.5 and embryos collected 12 h later at E11 (c, d). Coronal sections were double stained for EdU and Ki67 and cells from the medial dorsal telencephalon were assessed for expression of these two markers. The ratio of Ki67 + EdU+/EdU+ cells was significantly reduced in Akirin2 knockout embryos at both E10.5 (b) and E11 (d). Red boxes in (a and c) demarcate the regions quantified in (b and d); all analyzed cells were positive for the Cre reporter, tdTomato. ****p < 0.0001. Scale bar: 100 μm

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