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Fig. 5 | Neural Development

Fig. 5

From: Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

Fig. 5

FMRP KD tadpole cells show increased evoked inhibitory activity. a Example traces of inhibitory evoked activity (recorded at +5 mv), and excitatory (recorded at −45 mv) used to calculate the excitation-inhibition balance (top, control; bottom, FMRP KD). b Evoked inhibitory recurrent activity at +5 mV, PMW = 0.048, n = 11 (control), n = 17 (FMRP KD). c Evoked excitatory recurrent activity at -45 mV, n = 11 (control), n = 17 (FMRP KD). d Excitation to inhibition ratio, Pt = 0.009, n = 11 (control), n = 17 (FMRP KD). e Average charge of inhibitory responses calculated over bins of 100 msec following stimulus show altered time course of inhibitory responses in FMRP KD group

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Neural Development

ISSN: 1749-8104