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Fig. 3 | Neural Development

Fig. 3

From: Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

Fig. 3

Spontaneous synaptic activity in tectal neurons is similar between control and FMRP KD tadpoles. a Example spontaneous EPSCs recorded at -60 mV in the presence of GABAA receptor blocker, picrotoxin. b Example spontaneous IPSCs recorded at +5 mV, the reversal potential for excitatory currents. c Frequency of sEPSCs. n = 28 for each group, PMW = 0.6784. d Amplitude of sEPSCs. n = 28 for each group, PMW =0.1069. e Frequency of sIPSCs. n = 18 control, n = 27 FMRP KD, PMW =0.1789. f Amplitude of sIPSCs. n = 18 control, n = 27 FMRP KD, PMW =0.5740. g Excitatory recurrent activity, defined as the presence of a barrage of activity at least 200 ms in duration with a change in holding current of at least 10pA. n = 28 for each group, PMW =0.3136. h Inhibitory recurrent activity, defined as the presence of a barrage of activity at least 200 ms in duration with a change in holding current of at least 10pA. n = 18 control, n = 27 FMRP KD, PMW =0.5101

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Neural Development

ISSN: 1749-8104