TY - JOUR AU - Sokolowski, Katie AU - Tran, Tuyen AU - Esumi, Shigeyuki AU - Kamal, Yasmin AU - Oboti, Livio AU - Lischinsky, Julieta AU - Goodrich, Meredith AU - Lam, Andrew AU - Carter, Margaret AU - Nakagawa, Yasushi AU - Corbin, Joshua G. PY - 2016 DA - 2016/05/21 TI - Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei JO - Neural Development SP - 12 VL - 11 IS - 1 AB - Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as anxiety, depression or obesity. Despite many studies of hypothalamic development and function, the link between embryonic development and innate behaviors remains unexplored. Here, focusing on the embryonically expressed homeodomain-containing gene Developing Brain Homeobox 1 (Dbx1), we explored the relationship between embryonic lineage, post-natal neuronal identity and lineage-specific responses to innate cues. We found that Dbx1 is widely expressed across multiple developing hypothalamic subdomains. Using standard and inducible fate-mapping to trace the Dbx1-derived neurons, we identified their contribution to specific neuronal subtypes across hypothalamic nuclei and further mapped their activation patterns in response to a series of well-defined innate behaviors. SN - 1749-8104 UR - https://doi.org/10.1186/s13064-016-0067-9 DO - 10.1186/s13064-016-0067-9 ID - Sokolowski2016 ER -