Fig. 3From: The PHR proteins: intracellular signaling hubs in neuronal development and axon degenerationOverview of PHR protein signaling that regulates injury-induced axon degeneration in flies and mice. Shown are signaling pathways that mediate PHR protein function in axon degeneration. a Drosophila Highwire functions through both Dlk/Wallenda and NMNAT to regulate axon degeneration. b Phr1 functions through NMNAT2 to regulate axon degeneration. The MAP2K and MAPK that mediate Dlk/Wallenda function in axon degeneration remain unknown, but are likely to be either JNK or p38 MAPK based upon findings in the context of neuronal developmentBack to article page