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Fig. 3 | Neural Development

Fig. 3

From: Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons

Fig. 3

Forced expression of Kctd13 or Tnfaip1 leads to altered profiles of dendritic spines of layer II/III cortical neurons within the P17 mouse cortex. a Representative 3D reconstructions of the apical and basal dendrites of layer II/III neurons. b-c Compared with control condition, forced expression of Kctd13 or Tnfaip1 did not significantly affect the density on spines on apical dendrites (F 2,36 = 1.82; P = 0.1762 One-way ANOVA followed by Bonferroni post-hoc test). In contrast, there was a significant decrease in the density of spines on basal dendrites (F 2,37 = 4.87; P = 0.0132 One-way ANOVA followed by Bonferroni post-hoc test). d-e There was a significant interaction between overexpression of Kctd13 or Tnfaip1 and the proportions of dendritic spine morphologies on apical dendrites (F 6,136 = 2.941; p < 0.001 Two-way ANOVA followed by Bonferroni post-hoc test) (d), but not basal dendrites (F 6,148 = 1.334; P = 0.2457 Two-way ANOVA followed by Bonferroni post-hoc test) (e). Graph plots mean + SEM; * p < 0.05, * p < 0.005 compared to control; # p < 0.05, ## p < 0.005, ### p < 0.001 compared with Kctd13 and Tnfaip1. (>10 apical or basal dendrites analysed for each condition). Scale bar represents 10 μm

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