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Fig. 4 | Neural Development

Fig. 4

From: Deltex1 is inhibited by the Notch–Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation

Fig. 4

Dtx1 induces the premature differentiation of neuronal precursors. Embryos were examined through in situ hybridization by using neurogenin1 and immunohistochemistry by using an anti-HuC/D antibody. a Compared with the controls, neurogenin1 expression level was increased at the bud stage but downregulated in dtx1 full-injected embryos. By contrast, a significant upregulation of HuC/D signals was detected in dtx1 full cRNA-injected embryos. b The results in a were confirmed using qPCR and cell count. Quantitative data are presented as mean ± standard deviation normalized to the number of controls. *, P < 0.05; **, P < 0.01

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Neural Development

ISSN: 1749-8104