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Fig. 6 | Neural Development

Fig. 6

From: Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons

Fig. 6

Pax6 −/− thalamic axons can exit the diencephalon in Pax6 −/− ↔Pax6+/+ chimeras. GFP staining shows tauGFP Pax6 −/− axons arising from small clusters of mutant cells in the thalamus: in (a), arrows mark the positions of regions imaged in slightly different planes of section in panels (b) and (e) and the boxed area is shown in panels (c) and (d). GFP+ Pax6 −/− axons were able to exit the thalamus and enter the internal capsule (IC) with a trajectory that overlapped the normal L1+ thalamocortical tract. DTB: diencephalic-telencephalic border. Scale bars: A, 500 μm; B, 50 μm; C,D, 100 μm; E, 75 μm

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Neural Development

ISSN: 1749-8104