From: An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system
Prdm gene | Nervous system expression | Nervous system function | Intrinsic HMT activity | Direct DNA binding | References |
---|---|---|---|---|---|
Prdm1 | CNS: photoreceptors | CNS: photoreceptor identity | No | Yes | |
PNS: prechordal plate, branchial arches, Rohon-Beard neurons | PNS: branchial arch formation, Rohon-Beard specification | Â | Â | ||
Prdm3 | CNS: telencephalon, tegmentum, diencephalon, hindbrain | CNS: olfactory receptor development | Â | Yes | |
PNS: branchial arches | PNS: craniofacial development | Â | Â | ||
Prdm4 | CNS: cerebral cortex | CNS: in vitro neural stem cell proliferation and differentiation | Yes | Â | |
Prdm5 | CNS: ventral spinal cord | PNS: development of the neuocranium | Â | Yes | |
PNS: neurocranium | |||||
Prdm6 | CNS: spinal cord neurons | Â | Yes | Yes | |
Prdm8 | CNS: telencephalon, retina, tegmentum, cerebellum, hindbrain and spinal cord | CNS: axonal outgrowth, neocortical neuron morphology | No | Yes | |
Prdm10 | PNS: neural crest | CNS: primary dendrite initiation | Â | Â | |
Prdm12 | CNS: telencephalon, tegmentum, cerebellum, midbrain, hindbrain and spinal cord p1 domain | CNS: formation of V1 interneurons, pain perception and sensory neuron development | Â | Â | |
PNS: cranial placodes | |||||
Prdm13 | CNS: tegmentum, hindbrain, spinal cord, retina | CNS: GABAergic interneuron development | Â | Yes | |
Prdm14 | CNS: ventral spinal cord | CNS: CaP motor neuron axonal projection | Â | Yes | |
Prdm16 | CNS: forebrain, telencephalon, hindbrain, retina | CNS: olfactory neuron development | Yes | Yes | |
PNS: craniofacial structures | PNS: craniofacial development |