Skip to main content

Table 1 Summary of Prdm gene expression and function in the nervous system

From: An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system

Prdm gene

Nervous system expression

Nervous system function

Intrinsic HMT activity

Direct DNA binding

References

Prdm1

CNS: photoreceptors

CNS: photoreceptor identity

No

Yes

[8, 108, 109, 120, 144–147]

PNS: prechordal plate, branchial arches, Rohon-Beard neurons

PNS: branchial arch formation, Rohon-Beard specification

  

Prdm3

CNS: telencephalon, tegmentum, diencephalon, hindbrain

CNS: olfactory receptor development

 

Yes

[28, 34, 120, 148]

PNS: branchial arches

PNS: craniofacial development

  

Prdm4

CNS: cerebral cortex

CNS: in vitro neural stem cell proliferation and differentiation

Yes

 

[149–151]

Prdm5

CNS: ventral spinal cord

PNS: development of the neuocranium

 

Yes

[9, 152, 153]

PNS: neurocranium

Prdm6

CNS: spinal cord neurons

 

Yes

Yes

[74, 154]

Prdm8

CNS: telencephalon, retina, tegmentum, cerebellum, hindbrain and spinal cord

CNS: axonal outgrowth, neocortical neuron morphology

No

Yes

[15, 47, 72, 74, 120, 155]

Prdm10

PNS: neural crest

CNS: primary dendrite initiation

  

[156, 157]

Prdm12

CNS: telencephalon, tegmentum, cerebellum, midbrain, hindbrain and spinal cord p1 domain

CNS: formation of V1 interneurons, pain perception and sensory neuron development

  

[73, 74, 81, 120, 158, 159]

PNS: cranial placodes

Prdm13

CNS: tegmentum, hindbrain, spinal cord, retina

CNS: GABAergic interneuron development

 

Yes

[43, 74, 80, 120]

Prdm14

CNS: ventral spinal cord

CNS: CaP motor neuron axonal projection

 

Yes

[46, 74, 120]

Prdm16

CNS: forebrain, telencephalon, hindbrain, retina

CNS: olfactory neuron development

Yes

Yes

[28, 34, 74, 120, 160]

PNS: craniofacial structures

PNS: craniofacial development

  1. Blank cells indicate categories were information is lacking in the literature. The list of expression domains and functions is not exhaustive