Fig. 2
From: An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system
Summary of Prdm expression domains and interactions. a. Schematic representation of Prdm and bHLH expression domains along the dorsoventral axis of the neural tube. b. Diagrams of interactions between Prdm and bHLH genes discussed in the text. Left panel: The Prdm13 gene is regulated by Ptf1a. Additionally, Prdm13 regulates both Tlx1 and Tlx3 expression – in the latter case Prdm13 acts in a complex with Ascl1. Middle panel (top): Prdm8 acts in a complex with Bhlhb5 to regulate Cdh11 expression. Middle panel (bottom): Prdm14 binds the promoter region of Islet2 to regulate its expression. Right panel: Prdm1a and zebrafish Olig4 cross repress each other’s expression at the neural plate boundary