Fig. 8
From: Netrin-1 directs dendritic growth and connectivity of vertebrate central neurons in vivo
Altered netrin-1 levels and DCC signaling impact postsynaptic cluster remodeling. a–d Confocal projections of single branches from representative tectal neurons co-expressing tdTomato (red) and PSD95-GFP (green) from control (a), netrin (b), UNC5H2-Ig (c), or Anti-DCC (d) groups before and after treatment. Dynamic remodeling of postsynaptic specializations is illustrated by the addition (green arrowheads) and elimination (yellow arrowheads) of PSD95-GFP clusters. Blue arrowheads denote puncta that remained stable from one observation interval to the next; white arrowheads denote puncta that were present at the initial observation time point but were eliminated (yellow) at 2 h. Scale bar: 20 μm