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Figure 7 | Neural Development

Figure 7

From: The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex

Figure 7

Failure of proper cortical neuron specification in the absence of MBD3. Pregnant mice were injected with BrdU once at E13.5 and the embryos examined at E18.5. (A) Representative immunostaining of E18.5 coronal brain sections for BrdU (red) and upper-layer neuronal marker BRN2 (white). (B) Representative immunostaining of E18.5 coronal brain sections for BrdU (red), TBR1 (green) and SATB2 (white). (C) Quantification of the percentage of cortical plate BrdU+ cells which are also positive for TBR1 (*P = 0.0210, df = 2) or positive for both TBR1 and SATB2 (*P = 0.0016, df = 2) per 100 μm of cortical length. The white lines indicate the presumptive lower boundary of the cortical plate. Scale bar = 100 μm; N = 3 to 6. Error bars represent st. dev.

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