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Figure 4 | Neural Development

Figure 4

From: The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex

Figure 4

Fewer Mbd3-deficient PAX6+ apical progenitors divide between E15.5 and E16.5. (A) Representative immunostaining of E14.5 and E16.5 coronal brain sections for Ki67. The white lines indicate the presumptive boundary between the VZ and outside in the VZ (non-VZ). (B) Quantification of the number of Ki67+ cells in the VZ per 100 μm of cortical length. N = 3 to 6, *P = 0.0199, df = 2. (C) Representative immunostaining of E14.5 and E16.5 coronal brain sections for BrdU (red) and Ki67 (green). The bottom panel is a magnified image of the boxed area in the above picture. (D) Quantification of the percentage of BrdU+/Ki67− cells in the VZ negative for Ki67 per 100 μm of cortical length (right panel). N = 3 to 6, *P = 0.0015, df = 2. Error bars represent st. dev. Scale bar = 100 μm.

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Neural Development

ISSN: 1749-8104