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Figure 9 | Neural Development

Figure 9

From: Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells

Figure 9

Delayed neurogenesis of Vsx2 orJ cells persists in the periphery of mutant chimeras. (A, B) EYFP and TUBB3 expression in the peripheral retina of control (A) and mutant (B) chimeras at E15.5. DAPI staining reveals a patch of Vsx2 orJ cells lacking TUBB3 (red brackets in B). (C) EYFP (green) and POU4F (magenta) expression in retina of a mutant chimera at E14.5. (a-inset, b-inset) Boxed regions in C. Arrows in a-inset indicate POU4F+ Vsx2 orJ cells in the neuroblast (white arrows) or differentiated (red arrows) cell layers. Red brackets in b-inset indicate peripheral patch of Vsx2 orJ cells lacking POU4F and TUBB3. Scale bars: 100 μm. Abbreviations: EYFP, enhanced yellow fluorescent protein.

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