Table 3 Functional annotation of mRNAs with altered stability based on neural-specific versus whole embryo measurements
From: Dynamic regulation of mRNA decay during neural development
| mRNAs stabilized in the nervous system (neural/whole embryo half-life >1.5) | |||||
|---|---|---|---|---|---|
| GO term | Definition | P value | FDR | Count | Fold enrichment |
| 007409 | Axonogenesis | 2 × 10−3 | .06 | 13 | 2.8 |
| APC, CadN, trio, caps, fray, otk, daw | |||||
| 0003924 | GTPase activity | 2 × 10−3 | .31 | 10 | 3.5 |
| Rab21, Rab30, Ras64B, RabX1 | |||||
| 0009312 | Oligosaccharide biosynthesis | 9 × 10−3 | .15 | 4 | 9.2 |
| mgat2, GalNAc-T1, pgant2, pgant5 | |||||
| 0045196 | Establishment of neuroblast polarity | .01 | .16 | 3 | 18.7 |
| par-6, baz, Lgl | |||||
| 0007269 | Neurotransmitter secretion | .04 | .56 | 6 | 2.6 |
| CanB, Lgl, CASK, Dap160, cpx, rop | |||||
| mRNAs destabilized in the nervous system (neural/whole embryo half-life <0.6) | |||||
| GO term | Definition | P value | FDR | Count | Fold enrichment |
| 0003735 | Structural constituent of ribosome | 5 × 10−17 | 5 × 10−15 | 26 | 9.2 |
| RpL11, RpL30, RpL6, RpS16, RpS23 | |||||
| 0000278 | Mitotic cell cycle | 4 × 10−8 | 4 × 10−5 | 30 | 3.2 |
| dap, cycB3, ball, glu, eff, ncd, mts | |||||
| 0031497 | Chromatin assembly | 3 × 10−4 | .02 | 7 | 7.5 |
| H2B, H3, H3.3A/B, HP2, Df31, Set | |||||
| 0005839 | Proteasome core complex | 8 × 10−3 | .07 | 5 | 6.0 |
| Pros26, Prosα7, Prosβ2, Prosβ7 | |||||
| 0006119 | Oxidative phosphorylation | 6 × 10−4 | .03 | 12 | 3.5 |
| ATPsynB, ATPsynD, mt:CoIII | |||||