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Table 3 Functional annotation of mRNAs with altered stability based on neural-specific versus whole embryo measurements

From: Dynamic regulation of mRNA decay during neural development

mRNAs stabilized in the nervous system (neural/whole embryo half-life >1.5)
GO term Definition P value FDR Count Fold enrichment
007409 Axonogenesis 2 × 10−3 .06 13 2.8
  APC, CadN, trio, caps, fray, otk, daw     
0003924 GTPase activity 2 × 10−3 .31 10 3.5
  Rab21, Rab30, Ras64B, RabX1     
0009312 Oligosaccharide biosynthesis 9 × 10−3 .15 4 9.2
  mgat2, GalNAc-T1, pgant2, pgant5     
0045196 Establishment of neuroblast polarity .01 .16 3 18.7
  par-6, baz, Lgl     
0007269 Neurotransmitter secretion .04 .56 6 2.6
  CanB, Lgl, CASK, Dap160, cpx, rop     
mRNAs destabilized in the nervous system (neural/whole embryo half-life <0.6)
GO term Definition P value FDR Count Fold enrichment
0003735 Structural constituent of ribosome 5 × 10−17 5 × 10−15 26 9.2
  RpL11, RpL30, RpL6, RpS16, RpS23     
0000278 Mitotic cell cycle 4 × 10−8 4 × 10−5 30 3.2
  dap, cycB3, ball, glu, eff, ncd, mts     
0031497 Chromatin assembly 3 × 10−4 .02 7 7.5
  H2B, H3, H3.3A/B, HP2, Df31, Set     
0005839 Proteasome core complex 8 × 10−3 .07 5 6.0
  Pros26, Prosα7, Prosβ2, Prosβ7     
0006119 Oxidative phosphorylation 6 × 10−4 .03 12 3.5
  ATPsynB, ATPsynD, mt:CoIII     
  1. Gene ontology categories were identified using DAVID. Representative genes are listed for each category. FDR is the Benjamini-Hochberg false discovery rate.