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Table 2 Neural-specific mRNA decay analysis: functional annotation of high-stability and low-stability mRNAs

From: Dynamic regulation of mRNA decay during neural development

Neural-specific measurements: low-stability mRNAs
GO term Definition P value FDR Count Fold enrichment
0006351 Transcription 4 × 10−10 2 × 10−7 58 2.5
  svp, dpn, pros, vvl, grh, gsb, onecut     
0030182 Neuron differentiation 2 × 10−7 4 × 10−5 48 2.3
  chinmo, Dl, tup, Ephrin, Eph, fax, shot     
0007067 Mitosis 6 × 10−5 3 × 10−3 21 2.9
  cycB3, cdc27, Sse, cnn, glu, mts     
0018024 Histone methyltransferase activity 2 × 10−4 .02 7 6.9
  G9a, Set1, Set2, Su(z)12, ash1, egg     
0006897 Endocytosis 4 × 10−3 .08 25 1.9
  Arpc4, shi, CalpA, pat1, faf, scb, Rac1     
0005840 Ribosome 2 × 10−3 .06 21 2.0
  RpL17, RpL35, mRpL11, mRpS35     
Neural-specific measurements: high-stability mRNAs
GO term Definition P value FDR Count Fold enrichment
0048812 Neuron projection morphogenesis 5 × 10−6 6 × 10−4 33 2.4
  trc, fusl, Fas2, Appl, Fmr1, otk, ben     
0003924 GTPase activity 2 × 10−4 .02 17 2.9
  Rab23, Rab30, Rab11, Rho1, Ras64B     
0012501 Programmed cell death 2 × 10−3 .06 17 2.4
  grim, pten, scyl, egr, mod(mdg4)     
0004672 Protein kinase activity 9 × 10−3 .24 23 1.8
  CamKI, Cdk4, Ror, ald, aur, nmo, trbl     
0019226 Transmission of nerve impulse .02 .25 17 1.8
  CASK, CanB, Dap160, cpx, Sap47     
0051674 Localization of cell .01 .16 18 1.9
  cbl, APC, cortactin, par-6, baz, spri     
  1. Gene ontology categories enriched among the 500 most stable and 500 least stable transcripts were identified using DAVID. Representative genes are listed for each category. FDR is the Benjamini-Hochberg false discovery rate.