Figure 1

Schematic representation of the human RTN4 gene and its zebrafish paralogues. All three major isoforms encoded in the RTN4 gene in humans (RTN4A, RTN4B and RTN4C) possess the reticulon homology domain (RHD), which includes the Nogo66 domain. The N-terminal region of RTN4A contains the Nogo-A-specific domain (yellow) and the neurite growth inhibitory Delta 20 (Δ20) stretch. The diagnostic M1 to M4 motifs are indicated in red. The zebrafish has two RTN4 paralogues: rtn4a and rtn4b. Rtn4a is produced in three different isoforms (Rtn4-l (blue), Rtn4-m (green) and Rtn4-n (orange)) with the same C-terminal RHD. Rtn4b also contains the M1 to M4 N-terminal motifs (red) and presents a distinct RHD.