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Figure 3 | Neural Development

Figure 3

From: STRAD pseudokinases regulate axogenesis and LKB1 stability

Figure 3

STRADα and STRADβ are redundant in axogenesis and limiting programmed cell death. Embryonic day 18.5 coronal sections immunolabeled for either corticofugal fibers (Tag1, green) (A-D, A’-D’) or activated caspase3 (Act-Casp3, green) (E-H, E’-H’) and a nuclear marker (DRAQ5, magenta in A-D, blue in E-H). Axons are normal in wild-type, STRADα KO and STRADβ cKO brains, but completely gone in the STRADα/STRADβ double KO brain (A-D). Scale bar = 100 μm. Activated caspase3 is largely absent from wild-type, STRADα KO and STRADβ cKO brain, but drastically increased in STRADα/β double KO cortex (E-H, E’-H’). Scale bar = 100 μm. Higher magnifications of cortical regions of TAG1 immunolabeling and activated caspase 3 are shown in grayscale to the right (A’-D’ and E’-H’).

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