Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling

Table 2 Differences in the expression patterns of central optic cup progenitor cells (OCPCs) of wild-type, single-mutant and double-mutant eyes

	NR markers		Ciliary epithelium markers				Optic cup progenitor cell TFs			D-Cyclins (protein)
Genotype	Hes5	β-Tubulin/ Shh	Msx1	Otx1	BMP4	Zic1	Chx10	Rax	Pax6	CyclinD3	CyclinD1
Wild-type	expressed	expressed	absent	absent	absent	absent	expressed	expressed	expressed	absent	expressed
Sox2^-/-; Ctnnb1^-/+	absent	absent	expressed	expressed	expressed	expressed	expressed	expressed	increased	expressed	increased
Sox2^-/+; Ctnnb1^-/-	expressed	expressed	absent	absent	absent	absent	expressed	expressed	expressed	absent	expressed
Sox2^-/-; Ctnnb1^-/-	absent	absent	absent	absent	absent	absent	expressed	expressed	increased	expressed	increased

ISSN: 1749-8104