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Figure 1 | Neural Development

Figure 1

From: Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling

Figure 1

Genome- wide expression analysis of E16.5 Sox2-mutant optic cups (OCs) confirms loss of neural retina (NR) fate, activation of ciliary epithelium (CE) primordium genes, and suggests activated WNT signaling. Global changes in gene expression in Sox2-ablated OCs undergoing NR-to-CE primordium cell fate conversion were analyzed by microarray. (A) Diagram of expansion of the peripheral OC/prospective CE (orange) at the expense of the central OC/prospective NR (blue) in mutants compared with controls. (B) Ontologies of increased transcripts (orange) are consistent with CE function, while those of decreased transcripts (blue) are consistent with NR function. (C) Subsets of aberrantly expressed genes suggest activated WNT signaling and perturbed cell cycle. Decreased Hes5 and Sox2, and unchanged Chx10, confirm the validity of the screen.

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Neural Development

ISSN: 1749-8104