| Ferret VAChT-Sap MEME at 37° | Stafford et al.[[26]]: Ames’ at 37° | Xu et al.[[39]]: Ames’ at 37° | |||
---|---|---|---|---|---|---|
All Bursts | P6 Saline | P6 Ferret VAChT-Sap | Wild-type | ß2 KO | Wild-type | ß2 (TG) |
Total Neurons | 463 | 355 | 258 ± 99 | 340 ± 161 | -- | -- |
Total Neurons Analyzed for Bursts | 457 | 336 | -- | -- | -- | -- |
Bursts Per Neuron | 10.37 ± 2.16 | 12.36 ± 1.22 | -- | -- | -- | -- |
Burst Frequency (bursts/min) | 0.69 ± 0.14 | 0.82 ± 0.08 | 1.00 ± 0.10 | 2.10 ± 0.70*** | 0.63 ± 0.06 | 0.72 ± 0.08 |
% Spikes in Bursts | 98.18 ± 0.61 | 95.28 ± 1.60 | 96.60 ± 1.0 | 79.60 ± 5.10*** | 73.52 ± 4.36 | 68.57 ± 4.01 |
Maximum Burst Spike Rate | 528.04 ± 85.41 | 528.48 ± 161.02 | -- | -- | -- | -- |
% of Total Burst Time >10 Hz | 61.42 ± 3.60 | 42.82 ± 3.54*** | 23.20 ± 6.50 | 11.50 ± 1.90*** | -- | -- |
% Bursts in Waves | 86.74 ± 3.20 | 76.34 ± 5.60 | 88.70 ± 3.60 | 36.10 ± 7.40*** | 94.53 ± 2.40 | 86.99 ± 2.70 |
Mean Burst Spike Rate (spikes/s) | 41.08 ± 7.12 | 27.84 ± 10.20 | -- | -- | 6.18 ± 1.08 | 5.26 ± 0.87 |
Burst Interspike Interval (ISI) (ms) | 72.20 ± 11.62 | 132.11 ± 23.90* | 192.70 ± 28.70 | 326.2 ± 59.9*** | 360 ± 120 | 650 ± 180* |
Mean Spike Rate (spikes/s) | 0.91 ± 0.31 | 0.69 ± 0.14 | 0.40 ± 0.09 | 0.43 ± 0.14 | 0.18 ± 0.04 | 0.18 ± 0.03 |
Burst Duration (s) | 1.94 ± 0.23 | 2.25 ± 0.19 | -- | -- | 2.47 ± 0.47 | 3.76 ± 1.60 |
 | P6 Saline | P6 Ferret VAChT-Sap | Wild-type | ß2 KO | Wild-type | ß2 (TG) |
Wave Bursts | Â | Â | Â | Â | Â | Â |
Burst Duration | 1.93 ± 0.23 | 2.14 ± 0.20 | 2.96 ± 0.25 | 3.18 ± 0.57 | -- | -- |
Burst Spike Rate | 37.14 ± 5.34 | 21.63 ± 2.60* | -- | -- | -- | -- |
Burst (ISI) | 67.71 ± 9.09 | 131.06 ± 21.76** | 189.20 ± 27.40 | 302.90 ± 55.50*** | -- | -- |
Burst Spike Rate from ISI | 15.98 ± 2.24 | 8.11 ± 1.33** | -- | -- | -- | -- |
Interburst Interval (IBI) | 154.43 ± 27.59 | 143.91 ± 10.34 | -- | -- | -- | -- |
Maximum Burst Spike Rate | 529.49 ± 66.71 | 456.35 ± 140.18 | -- | -- | -- | -- |
% Neurons Bursting Per Second In Waves | 5.01 ± 0.35 | 3.04 ± 0.15*** | -- | -- | -- | -- |
Bursts Per Neuron Per Wave | 1.12 ± 0.07 | 1.17 ± 0.14 | 1.02 ± 0.02 | 1.18 ± 0.12** | -- | -- |
Percent Burst Time >10 Hz | 60.17 ± 3.60 | 42.37 ± 3.22*** | 78.30 ± 4.20 | 41.60 ± 7.20*** | -- | -- |
Non-Wave Bursts | Â | Â | Â | Â | Â | Â |
Burst Duration | 1.99 ± 0.24 | 2.34 ± 0.20 | 2.68 ± 0.18 | 2.38 ± 0.40* | -- | -- |
Burst Spike Rate | 46.14 ± 10.29 | 31.83 ± 17.60 | -- | -- | -- | -- |
Burst ISI | 77.88 ± 14.38 | 144.92 ± 32.94* | 204.40 ± 33.10 | 338.10 ± 66.10*** | -- | -- |
Burst Spike Rate from ISI | 46.14 ± 29 | 31.83 ± 17.60 | -- | -- | -- | -- |
Maximum Burst Spike Rate | 496.95 ± 117.20 | 583.86 ± 188.27 | -- | -- | -- | -- |
Percent Burst Time >10 Hz | 59.43 ± 4.75 | 40.89 ± 3.93** | 21.70 ± 4.20 | 58.10 ± 7.20*** | -- | -- |
 | P6 Saline | P6 Ferret VAChT-Sap | Wild-type | ß2 KO | Wild-type | ß2 (TG) |
Wave size (% of channels) | 33.48 ± 2.03 | 13.33 ± 0.50*** | -- | -- | 41.32 ± 8.32 | 9.50 ± 1.37*** |
Wave frequency (per min) | 2.26 ± 0.56 | 4.43 ± 0.90 | 1.66 ± 0.30 | 0.80 ± 0.28*** | 0.82 ± 0.09 | 0.85 ± 0.16 |
Wave duration (s) | -- | -- | 13.00 ± 2.80 | 10.80 ± 3.30 | 10.05 ± 1.42 | 5.42 ± 0.63*** |