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Table 2 Comparison of RGC burst and wave properties recorded at P6 following SAC ablation in ferret retinae with previously published data from ß2KO and ß2(TG) transgenic mice

From: Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity

 

Ferret VAChT-Sap MEME at 37°

Stafford et al.[[26]]: Ames’ at 37°

Xu et al.[[39]]: Ames’ at 37°

All Bursts

P6 Saline

P6 Ferret VAChT-Sap

Wild-type

ß2 KO

Wild-type

ß2 (TG)

Total Neurons

463

355

258 ± 99

340 ± 161

--

--

Total Neurons Analyzed for Bursts

457

336

--

--

--

--

Bursts Per Neuron

10.37 ± 2.16

12.36 ± 1.22

--

--

--

--

Burst Frequency (bursts/min)

0.69 ± 0.14

0.82 ± 0.08

1.00 ± 0.10

2.10 ± 0.70***

0.63 ± 0.06

0.72 ± 0.08

% Spikes in Bursts

98.18 ± 0.61

95.28 ± 1.60

96.60 ± 1.0

79.60 ± 5.10***

73.52 ± 4.36

68.57 ± 4.01

Maximum Burst Spike Rate

528.04 ± 85.41

528.48 ± 161.02

--

--

--

--

% of Total Burst Time >10 Hz

61.42 ± 3.60

42.82 ± 3.54***

23.20 ± 6.50

11.50 ± 1.90***

--

--

% Bursts in Waves

86.74 ± 3.20

76.34 ± 5.60

88.70 ± 3.60

36.10 ± 7.40***

94.53 ± 2.40

86.99 ± 2.70

Mean Burst Spike Rate (spikes/s)

41.08 ± 7.12

27.84 ± 10.20

--

--

6.18 ± 1.08

5.26 ± 0.87

Burst Interspike Interval (ISI) (ms)

72.20 ± 11.62

132.11 ± 23.90*

192.70 ± 28.70

326.2 ± 59.9***

360 ± 120

650 ± 180*

Mean Spike Rate (spikes/s)

0.91 ± 0.31

0.69 ± 0.14

0.40 ± 0.09

0.43 ± 0.14

0.18 ± 0.04

0.18 ± 0.03

Burst Duration (s)

1.94 ± 0.23

2.25 ± 0.19

--

--

2.47 ± 0.47

3.76 ± 1.60

 

P6 Saline

P6 Ferret VAChT-Sap

Wild-type

ß2 KO

Wild-type

ß2 (TG)

Wave Bursts

      

Burst Duration

1.93 ± 0.23

2.14 ± 0.20

2.96 ± 0.25

3.18 ± 0.57

--

--

Burst Spike Rate

37.14 ± 5.34

21.63 ± 2.60*

--

--

--

--

Burst (ISI)

67.71 ± 9.09

131.06 ± 21.76**

189.20 ± 27.40

302.90 ± 55.50***

--

--

Burst Spike Rate from ISI

15.98 ± 2.24

8.11 ± 1.33**

--

--

--

--

Interburst Interval (IBI)

154.43 ± 27.59

143.91 ± 10.34

--

--

--

--

Maximum Burst Spike Rate

529.49 ± 66.71

456.35 ± 140.18

--

--

--

--

% Neurons Bursting Per Second In Waves

5.01 ± 0.35

3.04 ± 0.15***

--

--

--

--

Bursts Per Neuron Per Wave

1.12 ± 0.07

1.17 ± 0.14

1.02 ± 0.02

1.18 ± 0.12**

--

--

Percent Burst Time >10 Hz

60.17 ± 3.60

42.37 ± 3.22***

78.30 ± 4.20

41.60 ± 7.20***

--

--

Non-Wave Bursts

      

Burst Duration

1.99 ± 0.24

2.34 ± 0.20

2.68 ± 0.18

2.38 ± 0.40*

--

--

Burst Spike Rate

46.14 ± 10.29

31.83 ± 17.60

--

--

--

--

Burst ISI

77.88 ± 14.38

144.92 ± 32.94*

204.40 ± 33.10

338.10 ± 66.10***

--

--

Burst Spike Rate from ISI

46.14 ± 29

31.83 ± 17.60

--

--

--

--

Maximum Burst Spike Rate

496.95 ± 117.20

583.86 ± 188.27

--

--

--

--

Percent Burst Time >10 Hz

59.43 ± 4.75

40.89 ± 3.93**

21.70 ± 4.20

58.10 ± 7.20***

--

--

 

P6 Saline

P6 Ferret VAChT-Sap

Wild-type

ß2 KO

Wild-type

ß2 (TG)

Wave size (% of channels)

33.48 ± 2.03

13.33 ± 0.50***

--

--

41.32 ± 8.32

9.50 ± 1.37***

Wave frequency (per min)

2.26 ± 0.56

4.43 ± 0.90

1.66 ± 0.30

0.80 ± 0.28***

0.82 ± 0.09

0.85 ± 0.16

Wave duration (s)

--

--

13.00 ± 2.80

10.80 ± 3.30

10.05 ± 1.42

5.42 ± 0.63***

  1. The table list mean values ± SEM for all parameters recorded. Statistics reflect two-tailed P values calculated from independent two-sample Student’s t-tests (*P <0.05, **P <0.01, ***P <0.001). P6, postnatal day 6; P10, postnatal day 10; ISI, interspike interval; IBI, interburst interval.