Figure 5

Effects of Ferret VAChT-Sap treatment on retinal ganglion cell burst properties. SAC ablation leads to small declines in the fraction of total spikes occurring in bursts (a), as well as the fraction of bursts occurring in waves (b). SAC ablation does not impact the mean duration of bursts in waves (c) and the mean spike rate within wave bursts is similar to controls (d). SAC ablation significantly reduces high frequency firing (>10 Hz) within bursts relative to controls (e). Data points reflect mean values ± SEM; the number of retinae/animals recorded for Ferret VAChT-Sap and Saline conditions at P2 was N = 6 and 5, P4 N = 7 and 4, P6 N = 7 and 6, P8 N = 7 and 6, and P10 N = 4 and 2 respectively. Statistics reflect two-tailed P values calculated from independent two-sample Student’s t-tests (*P <0.05, ***P <0.001).