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Figure 4 | Neural Development

Figure 4

From: Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity

Figure 4

Ferret VAChT-Sap treatment disrupts spatiotemporal correlations in retinal waves. Retinal ganglion cell (RGC) pairs in saline control recordings exhibit correlated spontaneous activity that decreases as a function of inter-pair distance (black data points). At P2, treatment with Ferret VAChT-Sap does not perturb the structure of correlations within waves (red data points). Beginning at P4, the structure of correlations between RGC pairs in Ferret VAChT-Sap-treated retinae begins to shift such that by P10, correlations at all inter-pair intervals are reduced in Ferret VAChT-Sap-treated retinae compared to controls. Data points reflect mean values ± SEM; the number of retinae/animals recorded for Ferret VAChT-Sap and Saline conditions at P2 was N = 6 and 5, P4 N = 7 and 4, P6 N = 7 and 6, P8 N = 7 and 6, and P10 N = 4 and 2 respectively.

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