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Figure 8 | Neural Development

Figure 8

From: Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits

Figure 8

Isl2-GFP+retinal ganglion cells (RGCs) project to the medial tegmental nucleus (MTN) and olivary pretectal nucleus (OPN) early in development. (A-C) Coronal sections through the SCN of P2 (A), P6 (B) and P12 (C) Isl2-GFP mice in which all RGCs were labeled with CTB-555 (red) reveal a lack of innervation at any point by Isl2-GFP+ RGCs (green). (D-F) Coronal sections thought the MTN of P2 (D), P6 (E) and P12 (F) Isl2-GFP mice in which all RGCs were labeled with CTB-555 reveals an early innervation by Isl2-GFP+ RGCs. (G-I) Coronal sections through the OPN of P2 (G), P6 (H) and P12 (I) Isl2-GFP mice in which all RGCs were labeled with CTB-555 reveal an early innervation by Isl2-GFP+ RGCs which is quickly pruned by P6. D, dorsal; M, medial; bar, 200 μm.

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