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Figure 6 | Neural Development

Figure 6

From: Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain

Figure 6

Optix is required for cell survival and adhesion within the neuroepithelium. (A-C”’) Control (FRTG13) and Optix1 null mutant MARCM clones were induced in the neuroepithelium (labelled with mCD8-GFP in green). Cells are outlined by Dlg (red), neuroblasts labelled by Dpn (blue). (A-A”’) Wild type clones remain in the neuroepithelium. (B-B”’) Optix1 mutant clones delaminate from the neuroepithelium and show signs of apoptosis, such as cellular fragmentation. (C-C”’) Optix1 mutant clones induced in the lateral neuroepithelium (lateral to the lamina furrow, indicated by yellow arrowhead) do not delaminate or show signs of cell death. Posterior cross-sections are shown in all images. The apico-basal axis of the neuroepithelium is oriented vertically in each image, with the apical surface at the top and the basal surface at the bottom. Scale bars: 30 μm.

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