Figure 6

p75^−/−mice have fewer taste buds, and some of their existing taste buds are un-innervated. (A,B,C) Cytokeratin 8-labeled taste buds (green), P2X3-labeled gustatory nerve fibers (red) and cell nuclei (DAPI, blue) can be seen in the lingual epithelium from a wild-type (A) and p75^−/−(B,C) mouse. (D) p75^−/−mice had fewer taste buds than wild-type mice. (E) p75^−/−mice had similarly sized innervated taste buds but smaller un-innervated taste buds compared with wild-type mice. Scale bar = 10 μm for A-C. **P ≤ 0.01.