Figure 10
From: Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development
A working model for the influences of Sonic hedgehog (Shh)-Smoothened signaling in neuron development from ventral midbrain. (A) Shh-Smoothened signaling exerted spatial and temporal influences on the progenitors in vMB at embryonic day (E)11.5 to 12.5. (B) Loss of Shh-Smoothened signaling resulted in more pronounced and persistent effect of differentiated neurons in the oculomotor nucleus (CNIII), red nucleus (RN), and the raphe nuclei. PAG, periaqueductal grey; SN, substantia nigra; VTA, ventral tegmental area.