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Figure 2 | Neural Development

Figure 2

From: Histamine up-regulates fibroblast growth factor receptor 1 and increases FOXP2 neurons in cultured neural precursors by histamine type 1 receptor activation: conceivable role of histamine in neurogenesis during cortical development in vivo

Figure 2

HA activates H 1 R to increase the number of clones with differentiated neurons. (A) Significant increase in the number of colonies with microtubule associated protein 2 (MAP2)+ neurons promoted by HA and its prevention by chlorpheniramine (Chlorph.) **P <0.01 and ***P <0.001 versus Control. (B-D) Representative micrographs of clonal colonies after immunocytochemical detection of mature neurons (MAP2+; red), astrocytes (GFAP+; green) and nuclei (blue) in Control (B), HA-treated (C) and HA + chlorpheniramine (Chlorph.)-treated (D) cells are shown. Scale bar = 100 μm. GFAP, glial fibrillary acidic protein; HA, histamine; H1R, histamine receptor type 1.

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