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Figure 2 | Neural Development

Figure 2

From: Neurosensory development and cell fate determination in the human cochlea

Figure 2

SOX2 and SOX9 expression during development of the human organ of Corti (OC). (A,B) Apical turn of a W14 cochlea immunostained for (A) SOX2 and (B) SOX9 and magnification of the prosensory domain/OC (A′,B′). Cell nuclei were visualized (red) with TO-PRO-3. (C) The prosensory domain/OC in the apical turn of a W14 cochlea immunostained for SOX9 (green) and MYO7A (red). Cell nuclei were visualized with DAPI (blue). (D,E) Middle turn of a W14 cochlea immunostained for (D) SOX2 and (E) SOX9, and (D′,E′) magnification of the prosensory domain/OC. Cell nuclei were visualized with TO-PRO-3 (red). (F) The prosensory domain/OC in the middle turn of a W14 cochlea immunostained for SOX9 (green) and MYO7A (red). Cell nuclei were visualized with DAPI (blue). (G,H) Basal turn of a W14 cochlea immunostained for (G) SOX2 and (H) SOX9, and (G′,H′) magnification of the prosensory domain/OC. (I) The prosensory domain/OC in the basal turn of a W14 cochlea immunostained for SOX9 (green) and MYO7A (red). Cell nuclei were visualized with DAPI (blue). (J,K) Basal turn of a W19 cochlea immunostained for (G) SOX2 and (H) SOX9. Cell nuclei were visualized with TO-PRO-3 (red). *Cytoplasmic SOX2 staining in the cochlear duct; bracket, the prosensory domain/OC; arrowhead, inner hair cell. Abbreviations: KO, Kölliker’s organ; IHC, inner hair cell; O1, first row of outer hair cells; O2, second row of outer hair cells; O3, third row of outer hair cells. Scale bars = (A–K) 50 μm or (A–H) 20 μm.

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