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Figure 4 | Neural Development

Figure 4

From: Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells

Figure 4

Conditional Dicer inactivation suppresses miR-124 and miR-138 signal in sympathetic neurons. In E16.5 mouse embryo, (A, D) Phox2b and (G, J) DBH ISH signal marks the position of the SCG in (A, G) control and (D, J) a mutant animal with homozygous inactivation of floxed Dicer by DBH promoter-driven Cre recombinase (DicercKO). (B, E) miR-138 and (H, K) miR-124 are detected by LNA-ISH in (B, H) control sympathetic neurons and reduced in (E, K) mutant ganglia. LNA-ISH with (C, F, I, L) scrambled sequence probe shows specificity of ISH signals. Scale bar: 100 μm.

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