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Figure 1 | Neural Development

Figure 1

From: Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells

Figure 1

Inverse mRNA ratios for Syt1 and Syt7 are found in P21 adrenal chromaffin cells and sympathetic neurons. (A) ISH for DBH mRNA marks noradrenergic sympathetic neurons in a prevertebral ganglion (black arrowhead) and chromaffin cells in the adrenal medulla (white arrowhead) at P21. Sympathetic neurons display strong signals for (B) NF-L, (C) NF-M and (D) SCG10 mRNAs, which are barely detectable in adrenal chromaffin cells. (E) Snap25 mRNA is detected at high levels in the majority of neurons and at intermediate levels in the majority of neuroendocrine cells, while (F) Syt1 mRNA is strongly expressed in neurons but only weakly in chromaffin cells. (G) Low expression levels of Syt7 mRNA in sympathetic ganglia contrast with medium to high signal strength in adrenal medulla. (H) Rab3a mRNA is detected at high levels in neurons but not above background in chromaffin cells. Scale bar: 100 μm.

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Neural Development

ISSN: 1749-8104